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Document Type |
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Thesis |
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Document Title |
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The Effect of Type 1 Diabetes Mellitus on Cognition and Vitamin D Level among Adults in Makkah City تأثير مرض السكر من النوع الأول على الإدراك المعرفي ومستوى فيتامين د في البالغين في مدينة مكة |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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Type 1 diabetes mellitus (T1DM) has spread widely worldwide with a continuous and rapid increase in the rate of incidence across the population. In Saudi Arabia, the prevalence of T1DM has increased among children and adolescents. The brain is one of the main organs that are affected by the long-term complications of diabetes, which manifest as cognitive impairment. Vitamin D has recently been linked to several autoimmune diseases such as T1DM. As a result, vitamin D supplementation may help to prevent the development of T1DM and reduce its complications, including cognitive impairment. In the current study, we aimed to assess the cognition of Saudi adults with T1DM using the Brief Cognitive Status Exam (BCSE) in Makkah city, and to examine the association between vitamin D and cognitive impairment in patients with T1DM. Our cross-sectional study included adult Saudi patients with T1DM between the ages (16-37 years) old, (n= 100) of both genders " males (n=41)" and "females (n=59)" who have followed-up for more than 6 months in the Alnoor diabetic center and Hiraa diabetic center in Makkah city. It was carried out from April until October 2021. Participant's data were collected from the medical records files, which included information about the type of diabetes, and the level of 25-hydroxyvitamin D. Each participant was provided with a questionnaire including some dibatic-related demographic variables. Moreover, patients had to complete the BCSE. Chi-square tests were used to determine the association between T1DM and cognitive impairment and vitamin d level. The current study results indicated that 63% of the participants had low levels of cognition. There was a significant association and positive correlation between T1DM and cognitive impairment (p= 0.029, r=0.209). The study also demonstrated that there is a significant association between vitamin D deficiency and low levels of cognition among patients with T1DM estimated by (p=0.000). In conclusion, T1DM significantly affects cognitive function. In addition, vitamin D deficiency might be a risk factor for cognitive impairment in T1DM. Further research on T1DM to the association between vitamin D and cognitive impairment among T1DM patients is needed. Also, it is recommended that cognitive function has to be assessed on a routine basis to prevent further behavioral complications. |
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Supervisor |
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Dr. Amani Ahmad Filimban |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1444 AH
2023 AD |
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Co-Supervisor |
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Dr. Shereen Ahmad Azhari |
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Added Date |
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Thursday, June 29, 2023 |
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Researchers
| روان Owaid السلمي | Alsulami, Rawan عويد | Researcher | Master | |
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