Document Details

Document Type : Thesis 
Document Title :
Histological Study of the Possible Protective Effect of Peel Extract of Pomegranate (Punica granatum) on the Liver of Diabetic Rats
دراسة نسيجية عن التأثير الوقائي المحتمل لمستخلص قشر الرمان (بونيكا غراناتوم) على كبد الجرذان المصابة بداء السكري
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : Back ground: Diabetes mellitus result from disorders in insulin secretion or receptors and characterized by hyperglycemia. Pomegranate is considered a hypoglycemic agent, based on its antioxidant activity. Objectives: The aim of study was to investigate the possible effect of pomegranate peel extract (PPE) in controlling hyperglycemia and liver histological changes in diabetic rat model. Method: Sixty adult male rats were divided into five groups. Group1: served as control, Group 2: was given PPE (200 mg/kg). Group 3: Diabetic; induced by 55 mg/kg /BW intraperitoneal injection of (STZ), Group4; Protective; PPE (200 mg/kg) for 11 weeks daily before the induction of diabetes. Group 5: treated after induction of diabetes with the same dose of PPE. The effectiveness of pomegranate peel extract was assessed by recording body weight, blood glucose level and liver enzymes (alanine aminotransferase (ALT), alkaline phosphatase (ALP) and aspartate aminotransferase (AST). Histopathological alterations of liver tissue using hematoxylin and eosin (H&E), Masson trichrome for collagen and periodic acid Schiff (PAS) for polysaccharides. Results: Blood glucose level and liver enzymes levels were significantly elevated in G3: diabetic group. In G2:( PPE group) and G4:(PD group) sugar level was normal. In contrast, G5 (DP group) and G4 (PD group) showed a lower levels of liver enzymes compared to (G:3). Moreover, histopathological examination of diabetic rat livers. showed several alterations (necrosis, congestion, increased collagen and decreased PAS reaction) while, PPE administration given either prior (G4) or after (G5) diabetes induction showed remarkable reduction of those alterations. Conclusion: PPE was found to be effective in controlling hyperglycemia, alteration in liver enzymes and histological changes with more protective rather than therapeutic activity. Such results make PPE a promising new strategy as a supplement for controlling and preventing diabetes induced hepatic changes. 
Supervisor : Dr. Khadija Abdul jalil Faddladdeen 
Thesis Type : Master Thesis 
Publishing Year : 1440 AH
2019 AD
Added Date : Thursday, July 4, 2019 


Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
أحلام عبدالعزيز عجيميOjaimi, Ahlam AbdulazizResearcherMaster 


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