Document Details

Document Type : Thesis 
Document Title :
BIOCHEMICAL TOXICOLOGICAL AND PHARMACOLOGICAL EVALUATION OF LEVOCETIRIZINE AND AMLODIPINE ON STRESS INDUCED CARDIAC REMODELING IN MALE WISTAR RATS
التقييم الكيميائي الحيوي والسمي والدوائي لليفوسيتريزين وأملوديبين في إعادة النمذجة القلبية المستحثة بالإجهاد في جرذان ويستار الذكور
 
Subject : Faculty of Sciences 
Document Language : Arabic 
Abstract : especially to the clinician who encounters patients with multiple disease symptoms. In our study, we tried to assess the toxic/beneficial effect of a prominent calcium channel blocker–Amlodipine (Amlo), when administered with Levocetirizine (Levo)–an antihistamine drug, to forced swim-induced stress model of Albino Wistar rats. Methodology: Animals were subjected to forced swim-induced stress (FSIS) for remodelling in heart followed by amlodipine (3 mg/kg/day) and Levocetirizine (0.5 mg/kg/day) treatment for 90 days. Biochemical parameters like serum alkaline phosphatase, alanine transaminase, triglycerides, uric acid, serum amylase, sodium, potassium, calcium and total protein were assessed. The modulations in cellular architecture of heart and liver were studied histopathologically. Results: The overall alteration in serum alkaline phosphatase, alanine transaminase, triglycerides, and uric acid significantly demonstrated the protective role of this drug combination in the stress-induced remodelling of the heart. Elevated levels of alkaline phosphatase and alanine transaminase were observed in the single-drug therapeutic groups (P < 0.05). The combination therapy restored the biochemical parameters, revealing the synergistic effect. A similar trend of change was observed in the levels of amylase (P < 0.01). In support of the biochemical findings, our histopathology results revealed FSIS-AmloLevo group demonstrated near to normal cellular architecture with less fat depositions when compared to FSIS-Amlo and FSIS-Levo, Conclusion: The combination therapy of these drugs demonstrated a significant beneficial effect on stress-induced cardiac remodelling under the given set of conditions. 
Supervisor : Prof. Firoz Anwar 
Thesis Type : Doctorate Thesis 
Publishing Year : 1439 AH
2018 AD 
Co-Supervisor : Prof. Abdulrahman L. Al-Malki 
Added Date : Sunday, July 1, 2018 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عبدالعزيز سفران العرابيAL-ORABI, ABDULAZIZ SAFRANResearcherDoctorate 

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