Document Details

Document Type : Thesis 
Document Title :
BRCA1 AND BRCA 2 MUTATIONS IN BREAST CANCER PATIENTS IN JEDDAH SAUDI ARABIA
طفرات جين BRCA1 و BRCA2 في مريضات سرطان الثدي بجدة في المملكة العربية السعودية
 
Subject : Faculty of Sciences 
Document Language : Arabic 
Abstract : Breast cancer is one of the major severe malignancies that affect women and occurs in either sporadic or hereditary form. The later affects five to ten percent of all cases and have distinct characteristics as compared to sporadic breast cancer. The discoveries of BRCA1 and BRCA2 remain one of the most important ones in human cancer genetics. Determination of the most penetrant mutations in these tumor suppressor genes has had a great impact on the woman breast cancer risks and their families. This research presents the study done on the distribution of the alleles of BRCA1 and BRCA2 genes in a sporadic breast cancer population in Jeddah. The study included 128 participants (50% control, 50% patients) and used Tetra ARMS-PCR primers technique for the detection of the missense mutation, c.4132G>A, exon 11 for BRCA1 and c.1385A>G in exon 10 for BRCA2. The results of the study indicated that (100%) of the genotype was normal allele (GG) for BRCA1, (98.44%) of the genotype was normal allele (AA) for BRCA2 while the control had (1.56%) for hetero allele (GA). At the moment, however, there is no enough proof to conclude that BRCA1 and BRCA2 mutations occur at a substantially lower frequency in KSA compared to the rest of the world. 
Supervisor : Prof. Sabah Linjawi 
Thesis Type : Master Thesis 
Publishing Year : 1438 AH
2017 AD 
Co-Supervisor : Prof. Zuhoor algaithy 
Added Date : Thursday, June 15, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
نوره يحى حمديHamdi, Norah YahyaResearcherMaster 

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