Document Details
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Document Type |
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Thesis |
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Document Title |
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BIOCHEMICAL MARKERS OF BONE TURNOVER IN SAUDI FAMELS OF REPRODUCTIVE AGE USING ORAL CONTRACEPTIVE PILLS الدلالات الكيميائية الحيوية لمعدل بناء وهدم العظام في النساء السعوديات اللاتي يتناولن أقراص منع الحمل في سن الإنجاب |
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Subject |
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Faculty of Sciences |
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Document Language |
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Arabic |
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Abstract |
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Oral contraceptives (OCs) are used by non-oral contraceptives (NOC) women very often throughout a prolonged period of time and more frequently early in life, within the first reproductive years. According to the close relationship between estrogen and bone metabolism, the question of the impact of OCs on bone needs to be addressed. Therefore, the purpose of this study was to evaluate the changes of bone turnover markers (BTMs) among healthy premenopausal Saudi women using (OCs). Seventy five female participants (24–40 years) were categorized as (OCs) users (N=40) for at least one year and (NOC) controls (N=35). All Subjects completed a questionnaire on lifestyle characteristic at the Maternity and Children's Hospital in Almasadeya in Jeddah City included demographics, age, height, weight, body mass index (BMI), smoking history, caffeine use, milk consumption, vitamins D intake, supplement use, sun exposure, and exercise. Women with previous fractures, thyroid disease, hypertension and family history of osteoporosis were excluded. Main outcome measures included three markers of bone formation (osteocalcin, bone alkaline phosphatase (Bone ALP) and N-terminal propeptide of type I procollagen (PINP) and two markers of bone resorption that are Carboxy-terminal crosslinked telopeptide of collagen type I and N-terminal crosslinked telopeptide of type I collagen (NTXI). In addition, concentration of bone minerals (Calcium, Phosphorus and Magnesium), hormones and vitamin D3 levels were assessed. The mean serum bone minerals, parathyroid hormone (PTH) and vitamin D3 levels obtained from (OCs) users were lower slightly than those of the control group. Serum markers of bone turnover were increased slightly in (OCs) users compared to age-matched controls. However, significant increases in serum Bone ALP (4001±1443vs. 3140 ±1091 pg/ml in controls, p=.004) and serum CTXI (349±114 vs. 293±119 ng/ml in controls, p=.046) were observed in (OCs) users compared with (NOC) controls but the results still in normal range. We conclude that BTMs were not significantly influenced by using (OCs) in premenopausal Saudi women. |
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Supervisor |
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Prof. Dr. Nadia Nour Osman |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1438 AH
2017 AD |
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Added Date |
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Tuesday, February 21, 2017 |
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Researchers
| منال محمد الزهراني | Alzahrani, Manal Mohammed | Researcher | Master | |
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