Document Details

Document Type : Thesis 
Document Title :
Vitamin D Status in Pre-menopausal Women and its Association with the Metabolic Syndrome and its Individual Components: A Cross-Sectional Study
دراسة مقطعية لحالة فيتامين (د) في النساء قبل انقطاع الطمث والرابط بينه و بين متلازمة الأيض وعناصرها
 
Subject : MEDICAL Physiology 
Document Language : Arabic 
Abstract : OBJECTIVES: To assess vitamin D status in apparently healthy young group of Saudi pre-menopausal women and its correlation with the metabolic syndrome and its individual components. METHODS: A total of 205 pre-menopausal healthy Saudi women (20-45 years old) were enrolled in this study. We used a modified NCEP:ATPIII definition (modifications were in waist circumference ≥ 80 cm instead of ≥ 88 cm and fasting blood glucose level ≥ 100 mg/dL instead of ≥ 110 mg/dL) for the metabolic syndrome identification. Blood pressure was measured using an automated blood pressure monitor (Bp TRU, which has been validated by the British Hypertension Society). Fasting blood samples (10-12 hours of fasting) were collected for assessment of 25(OH)D status and other biochemical measurements (triglycerides, HDL-c and fasting blood glucose). RESULTS: Hypovitaminosis D was extensive in the study group; with a total of 92.2% of women with 25(OH)D levels <50nmol/L and 22.9% with 25(OH)D levels <12.5nmol/L. The metabolic syndrome was present in 7.8% of cases, with central obesity (waist circumference ≥ 80cm) being the most common component among the study group (46.3%), and a reduced HDL-c (<50 mg/dL) being the second most common component (28.8%). Raised triglycerides (≥150 mg/dL) were found in 9.3% of women, impaired fasting blood glucose (≥100 mg/dL) in 4.9% and high systolic blood pressure (≥ 130 mmHg) or high diastolic (≥85 mmHg) was found in 3.4% of women. Although not statistically significant, there was a negative correlation between vitamin D level and all components of the metabolic syndrome except HDL-c which was positively associated with vitamin D level. The prevalence of the metabolic syndrome and all its components (except a high BP) was higher in the severely vitamin D deficient group (<12.5 nmol/L) as compared to the mild to moderate deficiency group (12.5-49.99 nmol/L), however, this was only significant for the raised triglycerides and reduced HDL-c. Three out of five studied women (59%) had at least one component of the metabolic syndrome. CONCLUSION: These results confirmed the negative association between vitamin D levels and almost all the components of the metabolic syndrome. The high prevalence of vitamin D deficiency in this group is quite alarming and measures to correct it are indicated. Moreover, the high prevalence of central obesity may contribute, among other factors, to hypovitaminosis D. Measures to reduce obesity in this young group may improve vitamin D level as well as reducing the risk of the metabolic syndrome. 
Supervisor : Prof. Mohammad Saleh Ardawi 
Thesis Type : Master Thesis 
Publishing Year : 1433 AH
2012 AD 
Co-Supervisor : Dr. Hanan Ahmad Al-Kadi 
Added Date : Sunday, April 29, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
حنان محمد بالخيورBalkhyoor, Hanan MohammadResearcherMaster 

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