Document Details

Document Type : Article In Journal 
Document Title :
Expression of Apoptotic Signaling Protein p53 and cell proliferation associated protein KI-67 in oral lichen planus and oral squamous cell carcinoma
Expression of Apoptotic Signaling Protein p53 and cell proliferation associated protein KI-67 in oral lichen planus and oral squamous cell carcinoma
 
Document Language : English 
Abstract : Oral Lichen Planus (OLP) is a chronic inflammatory oral mucosal disease that appears in be related lo a cell mediated-immune process. In OLP destruction of the basal cell layer as well as changes in cell proliferation, cell repair and cell death occur in the injured mucosal epithelium. Histologically OLP is characterized by hyperkeratosis. basal cell liquefaction and intense infiltration of lymphocytes at epithelial- connective tissue interface. It has been suggested that OLP may be a premalignant lesion since oral squamous cell carcinoma (OSCC) have been observed in few patients affected by OLP. The aim of this study was to examine the expression of apoptotic signaling protein p53 and the cell proliferation associated protein Ki- 67 in OLP and OSCC in order to evaluate possible transition of OLP to OSCC. We examined epithelial cell proliferation using Ki-67 labelling index (1.1) in OLP and compared it to OSCC. Moreover we examined the expression of p53 in 01.P and OSCC to detect any association of p53 expression with increased cell proliferation. The present study was conducted on twenty patients who were divided into two groups . group I included 10 patients with 01. P with age range 36 to 64 years .while group 11 included 10 patients with OSCC with age range 44 to 70 years. Oral mucosal biopsies were obtained from till patients and immunohistochemically stained with p53 and Ki-67 antibodies. The number of p53 and Ki-67 positive cells in the basal and suprabasal layers of oral epithelium in 01.P and OSCC mucosal specimens \vas calculated. The results of the present study revealed that the mean of p53 expression in OSCC was significantly higher than in OLP(P= 0.002). similarly, the mean of Ki-67 expression in OSCC was significantly greater than in OLP (P =0.001). from the present work it can be concluded that the probability of neoplastic transformation of OLP is low. 
ISSN : 0 
Journal Name : Ainshams Dental Journal 
Volume : 8 
Issue Number : 1 
Publishing Year : 2005 AH
2005 AD 
Article Type : Article 
Added Date : Wednesday, June 18, 2008 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سوزان ابراهيمIbrahim, Suzan ResearcherDoctorate 
هدير الديسوقيEL-dessouky, Hadir InvestigatorDoctoratehfeldessoukg@kau.edu.sa

Files


Download This Page

Back To Researches Page