Faculty of applied studies

Document Details

Document Type : Article In Journal 
Document Title :
EVALUATION OF THE HEPATOPROTECTIVE POTENTIAL OF JIGRINE
تقييم إمكانات للكبد JIGRINEتقييم إمكانات للكبد JIGRINE
 
Subject : PHARMACY 
Document Language : English 
Abstract : Objective: To evaluate the hepatoprotective potential of jigrine pre-treatment on thioacetamide induced liver damage in rats. Methods: Albino rats (Wistar strain) were prophylactically treated with jigrine at two dose levels (0.5 ml and 1.0 ml/kg/day p.o.) for seven days. On days 6, rats were also given a single dose of thioacetamide (100 mg/ kg s.c.). Activity of jigrine against thioacetamide induced hepatotoxicity was also compared with silymarin (25 mg/kg/day p.o.). Biochemical parameters like serum AST, ALT, Na+, K+, tissue glutathione, tissue TBARS were estimated to assess the liver function. Biochemical observations were supplemented with histopathological examination of liver sections. Results: Thioacetamide administration increased the AST, ALT, Na+ and K+ levels in serum and TBARS in liver. Pre-treatment of the rats with jigrine or silymarin reduced the thioacetamide induced elevated levels of the above indices. Thioacetamide administration decreased the 
ISSN : 416-421 
Journal Name : Indian Journal of Pharmacology, 31: 416-421 
Volume : 1 
Issue Number : 1 
Publishing Year : 1420 AH
1999 AD
 
Article Type : Article 
Added Date : Wednesday, August 4, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
أفتاب أحمد عبدالسلامAbdulsalam, Aftab AhmedResearcherMaster 

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