Document Details

Document Type : Article In Journal 
Document Title :
Effect of itraconazole and terbinafine of Leishamania major promastigotes
تأثير عقاري اتراكونازول وتيربينافين على الطور السوطي لليشمانيا العظيمة
 
Subject : Leishmania 
Document Language : English 
Abstract : The antiporliferative effect induced in vitro by two antifungal compounds, the azole itraconazole and the allylamine terbinafine on Leishmania major promastigotes are reported. Treatment of promastigote cultures with itraconazole or with terbinafine induced growth arrest. Concentrations of 0.75 ul/l or more of itraconazole induced cell lysis after 72 hours. However, even relatively large concentrations of terbinafine (2.0 ul/l) did not induce cell lysis. The IC 50 for itraconazole and terbinafine were 0.31 ul/l and 3.3 ul/l respectively. 
ISSN : 1319-1004 
Journal Name : Journal of King Abdulaziz University: Medical Sciences 
Volume : 10 
Issue Number : 1 
Publishing Year : 1422 AH
2002 AD 
Article Type : Article 
Added Date : Sunday, February 21, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
هيثم أحمد زكائيZakai, Haytham AhmedInvestigatorDoctoratehzakai@kau.edu.sa
سمير خضر زموZimmo, Sameer KhedrResearcherDoctorate 

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