Document Details

Document Type : Article In Journal 
Document Title :
Distortion product otoacoustic emission for the screening of cochlear damage in children treated with cisplatin
Distortion product otoacoustic emission for the screening of cochlear damage in children treated with cisplatin
 
Subject : Otorhinolaryngology 
Document Language : English 
Abstract : OBJECTIVES/HYPOTHESIS: To detect subtle hearing changes by measuring otoacoustic emissions in patients treated with a first dose of cisplatin. STUDY DESIGN: Prospective study. METHODS: We recruited 26 patients (mean age at treatment, 11.3 years) into this prospective study conducted at a tertiary academic referral center. Audiograms and transient-evoked otoacoustic emissions (TEOAEs) and distortion-product otoacoustic emissions (DPOAEs) were measured before and after the first dose of cisplatin. RESULTS: Baseline readings were compared with those recorded after the administration of the first dose of cisplatin. Two patients showed a loss of TEOAEs at high frequencies above 4 kHz, and this was consistent with the 25-dB hearing loss of the high frequencies detected in their audiograms; there was a significant threshold shift for DPOAEs at a frequency >3 to 4 kHz (P <.05). CONCLUSIONS: DPOAE testing appears to be a more sensitive method to detect cochlear damage than conventional pure-tone audiometry. Our results suggest that the measurement of DPOAE thresholds is a useful approach to detect the early auditory changes induced by cisplatin therapy 
ISSN : 0023-852X 
Journal Name : The Laryngoscope 
Volume : 121 
Issue Number : 5 
Publishing Year : 1432 AH
2011 AD 
Article Type : Article 
Added Date : Wednesday, August 3, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
خالد النوريAl-Noury, Khalid ResearcherDoctorate 

Files

File NameTypeDescription
 30005.pdf pdf 

Back To Researches Page