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Document Type |
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Article In Journal |
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Document Title |
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Outcome of Cervix Cancer Patients Treated With High Dose Rate Brachytherapy Outcome of Cervix Cancer Patients Treated With High Dose Rate Brachytherapy at King AbdulAziz University Hospital |
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Subject |
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Radiation Therapy |
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Document Language |
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English |
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Abstract |
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Purpose: To review the treatment results of cervix cancer patients treated with high dose rate brachytherapy at King
Abdul Aziz University Hospital.
Methods: All cervix cancer patients treated with high dose rate brachytherapy at King Abdul Aziz university hospital
between January 2004 and December 2006 have been reviewed. The patient’s demographic data, treatment parameters
and follow up have been reported and histopathological grade and stage has been correlated with initial response
to treatment and disease Free survival has been calculated.
Results: Twenty four patients with mean age of 51.6 years. All patients had squamous cell carcinoma; 12.5% G1, 54.2%
G II and 33.3% G III. Stage IA 12.5%, IB 4.2%, IIA 16.7%, IIB 25%, IIIA 8.3%, IIIB 20.8% and IVA 12.5%, treatment toxicity was
diarrhea GII in 12.5% and G II cystitis in 21%.
Initial treatment response was 50% CR, 25% PR, 8.3% SD, and 16.7% DP.
After a mean follow up period of 39 months, the mean DFS was 27.3 months 95% confidence interval (CI) 23.52 – 31.07.
The median DFS was 29 months (95% CI , 23 – 35 months). Two year DFS was 60% and the 3 year DFS was 27%.
There was no correlation between DFS and histopathological grade (p = 0.53) or FIGO stage (p = 0.66), and no correlation
was found between DFS and response to treatment (p = 0.88). On multivariate analysis, histopathological grade,
FIGO stage, initial response all had no influence on DFS.
Conclusion: The use of external beam radiation therapy concomitant with weekly cisplatin followed by high dose rate
brachytherapy is an acceptable treatment modality for carcinoma of the cervix with mild treatment related toxicity |
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ISSN |
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0000-0000 |
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Journal Name |
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Saudi Journal of Obstetrics and Gynecology |
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Volume |
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11 |
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Issue Number |
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2 |
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Publishing Year |
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1430 AH
2009 AD |
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Article Type |
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Article |
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Added Date |
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Friday, July 29, 2011 |
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Researchers
| ياسر بهادر | Bahadur, Yasir | Investigator | Doctorate | yasirbahadur@hotmail.com |
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