Document Details Document Type : Article In Journal  Document Title : Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients   Subject : Diabetes Mellitus  Document Language : English  Abstract : AIMS: To determine the prevalence of autoantibodies in sera of Saudi diabetic patients including Type 1 and Type 2 diabetes mellitus (DM) and gestational diabetes mellitus (GDM) living in Jeddah, Saudi Arabia. Apart from data on the prevalence of islet-cell antibodies in patients in Ryhadh (Al-Attas et al. Frequency of islet cell antibodies in adult newly diagnosed diabetic patients. Ann Saudi Med 1990; 10: 369-373) immunological markers of autoimmune diabetes have not been explored in Saudi Arabians. METHODS: Autoantibodies to GAD65 (GADA) and IA-2 (IA-2A) were determined using radio-immunoprecipitation assays. RESULTS: In Type 1 DM patients, 54% were GADA+ and 27% were IA-2A+. A greater negative effect of disease duration was noted for IA-2A than for GADA positivity. Autoantibodies were more prevalent with younger age of onset. GADA were slightly more common in female Type 1 DM patients. In Type 2 DM, 8/99 patients were GADA+, and three of these patients with shorter disease duration were also IA-2A+. GADA, and particularly IA-2A, were associated with a younger age of onset of Type 2 DM and all the autoantibody-positive Type 2 DM patients were insulin-treated. GADA were detected in 2.2% of GDM patients, but none of these patients possessed IA-2A. CONCLUSIONS: The prevalence and associations of autoantibodies in Saudi diabetic patients are very similar to those reported for diabetic patients in other ethnic groups  ISSN : 1464-5491  Journal Name : Diabetic Medicine  Volume : 22  Issue Number : 4  Publishing Year : 1426 AH 2005 AD  Article Type : Article  Added Date : Sunday, April 3, 2011  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email حسن نصرت Nasrat, Hasan Researcher Doctorate   محمد العرضاوي Ardawi, Mohammed Researcher Doctorate   Files File Name Type Description  29505.pdf pdf   Back To Researches Page