Document Details

Document Type : Article In Journal 
Document Title :
Anti-TNF {alpha} antibody infliximab treatment for an infant with fistulising Crohn's disease.
Anti-TNF {alpha} antibody infliximab treatment for an infant with fistulising Crohn's disease.
 
Document Language : English 
Abstract : A female infant presented at the age of 4 weeks with dyschezia and bloody streaking of stools which did not improve on elemental formula for proposed cow’s milk protein allergy. At 6 months of age perianal ulceration appeared which evolved into multiple fistulas opening into the perineum. A diagnosis of infantile Crohn’s disease was made after colonoscopy and histopathology examination and exclusion of other conditions. An 8 week trial of total parenteral nutrition, in addition to corticosteroids, salazopyrine, metronidazole, and azathioprine failed to arrest deterioration of the perianal fistulas. Treatment with the anti-TNFα antibody infliximab was started at 5 mg/kg/dose at 9 months of age. She was given three doses at 0, 2, and 6 weeks, respectively. This resulted in significant healing of her fistulas and cessation of fistula output. This improvement was sustained at the time of last follow-up 10 months after treatment. 
ISSN : 4522111 
Journal Name : BMJ Case Reports 
Volume : 3 
Issue Number : 1 
Publishing Year : 1431 AH
2010 AD 
Article Type : Article 
Added Date : Thursday, November 18, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عمر سعادةSaadah, Omar IResearcherDoctoratesaadaho@hotmail.com

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