Document Details
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Document Type |
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Article In Journal |
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Document Title |
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POSTANTIBIOTIC EFFECTS OF DIFFERENT ANTIMICROBIAL AGENTS ON GRAM-NEGATIVE BACTERIA POSTANTIBIOTIC EFFECTS OF DIFFERENT ANTIMICROBIAL AGENTS ON GRAM-NEGATIVE BACTERIA |
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Document Language |
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English |
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Abstract |
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Abstract:
Objective:
Postantibiotic effects and postantibiotic subminimum inhibitory concentration effects of different antimicrobial agents on the regrowth of different types of clinical isolates.
Materials and Methods:
The postantibiotic effects (PAEs) were induced in Pseudomonas aeruginosa, Escherichia coil, Proteus mirabilis, and Klebsiella pneumoniae clinical isolates after treatment with lx-, 2X-, and 4X-MICs of fluoroquinolones (Trovafloxacin, levofloxacin and norfloxacin), amikacin, aztreonam, and B-Lactam antibiotics (cefamandole, ceftazidime, ceftriaxone, and ceftazime). The postantibiotic sub-MIC effects (PA SMEs) were studied by exposing the cultures in postantibiotic period to 0.1, 0.2, and 0.3 MICs of the tested antimicrobial agents.
Results:
Among the tested agents, the longest PAEs were observed after treatment with fluoroquinolones. The mean PAEs of the tested fluoroquinolones at concentrations of 1X-MICs on P. aeruginosa, E coil, P. mirabilis, and K pneumoniae isolates were in the ranges of 0.4-0.7, 0.6-0.8, 0.5-0.8, and 0.7-1.Oh, respectively, while longer-lasting PAEs were found after using the tested fluoroquinolones at a concentration of 4X-MIC (2.7-3.6, 3.0-3.9, 2.8-3.4, and 3.3-4.4h, respectively). The PAEs of amikacin are slightly weaker than that of fluoroquinolones. The PAEs values of aztreonam and the tested β -lactam antibiotics were significantly shorter than that of fluoroquinolones and amikacin (p <0.05). In case of PA SMEs, it was observed that their values were longer than the corresponding PAE values, especially at higher sub-MICs. The longest PA SMEs were induced after treatment with fluoroquinolones. The means PA SMEs of the tested fluoroquinolones at concentration of 0.1 MICs on P aeruginosa, E. coil, P mirabilis, and K pneumoniae isolates were in the ranges of 2.9-3.9, 3.2-4.3, 3.1-3.7, and 3.8-4.8h, respectively, while longer PA SMEs were found after treatment with 0.3MIC. Amikacin induce shorter PA SMEs as compared to that of fluoroquinolones. In case of aztreonam and the tested B-lactam antibiotics, their PA SMEs values were significantly shorter than that of fluoroquinolones and amikacin (p <0.05). |
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ISSN |
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0379-5284 |
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Journal Name |
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Arab. J. Lab. Med. |
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Volume |
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35 |
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Issue Number |
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1 |
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Publishing Year |
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1429 AH
2009 AD |
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Article Type |
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Article |
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Added Date |
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Sunday, May 30, 2010 |
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Researchers
| سليمان الشيخ | EL-sheikh, Soliman | Researcher | Doctorate | |
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