Document Details Document Type : Article In Journal  Document Title : Childhood Multiple Sclerosis. التصلب اللويحي لدى الأطفال   Document Language : English  Abstract : Childhood multiple sclerosis (MS) is a rare demyelinating autoimmune disease with different genetic risk factors and similar clinical and MRI findings to adult onset MS. Onset of MS is extremely uncommon in early childhood, particularly in those less than 10 years of age. The overall prevalence of MS varies significantly from 1-10 in 100,000 people in Japan to 248 in 100,000 in Canada. At least 5% of all MS patients have their first attack before 16 years of age with a female to male ratio of 1.4:1. Overall, childhood MS is being increasingly recognized. In this paper, an updated overview of childhood MS will be presented in the context of the available literature and our experience. Research into the earliest events in MS pathogenesis is needed to enhance our information of this disease. As well, understanding the triggers and initial immunologic targets involved may lead to the development of new therapies. Prospective longitudinal studies are required to evaluate the physical, cognitive, and psychosocial impact of childhood MS and the long term benefit of various therapeutic modalities.  ISSN : 0749-8063  Journal Name : Journal of Pediatric Neurology  Volume : 1  Issue Number : 5  Publishing Year : 2005 AH 2005 AD  Article Type : Article  Added Date : Saturday, March 13, 2010  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email محمد جان jan, Mohammed Researcher Doctorate   Files File Name Type Description  25911.doc doc   Back To Researches Page