Document Details

Document Type : Article In Journal 
Document Title :
Do eosinophil counts correlate differently with asthma severity by symptoms versus peak flow rate?
Do eosinophil counts correlate differently with asthma severity by symptoms versus peak flow rate?
 
Document Language : English 
Abstract : BACKGROUND: Discrepancy in asthmatic assessment by symptoms and peak flow rate (PFR) is a frequent dilemma. Currently, total peripheral eosinophil count (TPEC) is under study for asthma evaluation. OBJECTIVES: To explore the correlation between TPEC and asthma severity assessed by symptoms alone versus symptoms and PFR. METHOD: Adults asthmatics were selected from the Asthma Clinic. Severity assessment was based on two methods: symptoms alone or symptoms and PFR. Expiratory PFR was recorded by a Wright peak flow meter. Severity levels included mild intermittent, mild persistent, moderate persistent, and severe persistent. Total peripheral eosinophil count was performed on a Celldyn-3500 counter. Data was analyzed for statistical significance. RESULTS: Sixty asthmatics aged 15 to 70 years (mean = 34 years), of which 68.3% were female, were studied. Severity levels differed between the two assessment methods in 45% of the cases and showed a predominance of the moderate persistent type. Total peripheral eosinophil count ranged between 22 and 2470 cells/mm3 (mean = 520 +/- SD = 393) and eosinophilia was found in 50% of the cases. Total peripheral eosinophil count showed a high positive correlation with increased asthma severity level assessed by history alone (r = 0.460, P < .001); more than by history and PFR (r = 0.328, P < .05). CONCLUSION: The discrepancy between symptoms and PFR is confirmed by these results. A reliable objective parameter in asthma assessment is a continuous challenge. This study advocates the possible supplementation of TPEC as another objective parameter that might help in selecting the appropriate severity level in asthmatics 
ISSN : 1081-1206 
Journal Name : Annals of Allergy, Asthma and Immunology 
Volume : 83 
Issue Number : 1 
Publishing Year : 1420 AH
1999 AD 
Article Type : Article 
Added Date : Friday, October 16, 2009 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عماد كوشكKoshak, Emad InvestigatorDoctorate 
عمر العموديAlamoudi, Omer ResearcherDoctorate 

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