Document Details

Document Type : Article In Journal 
Document Title :
INCREASED FIBRIN TURNOVER IN PERIPHERAL ARTERIAL DISEASE: COMPARISON WITH A POPULATION STUDY
INCREASED FIBRIN TURNOVER IN PERIPHERAL ARTERIAL DISEASE: COMPARISON WITH A POPULATION STUDY
 
Subject : Vascular Surgery 
Document Language : English 
Abstract : Copley hypothesised the existence of an endoendothelial fibrin lining of blood vessels; while the Rokitansky-Duguid hypothesis suggests that ongoing fibrin formation on the arterial wall contributes to atherosclerosis. We assessed in vivo fibrin turnover by measurement of plasma levels of cross-linked fibrin degradation products (D-dimer antigen) using a sensitive immunoassay, in 68 patients with extensive atherosclerosis (chronic peripheral arterial disease) compared to 239 controls (a random population sample in the same area). Plasma D-dimer levels were significantly higher in patients than controls (p(O.OI) and correlated with clinical severity. We suggest that the plasma D-dimer level may be a useful index of intravascular fibrin turnover and of the ongoing contribution of thrombosis to arterial disease. 
ISSN : 1836-0291 
Journal Name : Clinical Hemorheology 
Volume : 12 
Issue Number : 1 
Publishing Year : 1412 AH
1992 AD 
Article Type : Article 
Added Date : Monday, August 24, 2009 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
حسن الزهرانيAl-Zahrani, Hasan InvestigatorDoctorate 

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 20320.pdf pdfIncreased fibrin turnover

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