Document Details Document Type : Article In Journal  Document Title : Growth hormone for children with chronic renal failure and on dialysis Growth hormone for children with chronic renal failure and on dialysis   Document Language : English  Abstract : We studied all children with CRF who received recombinant human growth hormone (rhGH) for more than a year (mean+/-SD duration of therapy 3.7+/-2.5 years) over an 11-year period. There were 32 children. Twenty-one children were conservatively managed, with a mean glomerular filtration rate (GFR) of 24+/-12 mL min(-1)/1.73 m2 at the start of rhGH. Their height standard deviation score improved from -2.5+/-1.4 to -2.1+/-0.7 at 1 year (P=0.3), -2.0+/-0.7 at 2 years (P=0.01), and -1.6+/-0.6 at 3 years (P=0.001). After that there was no improvement. Eleven children were on dialysis, six on haemodialysis (HD) and five on peritoneal (PD). Ht SDS improved from -2.7+/-0.5 to -2.3+/-0.5 at 1 year (P=0.02). Thereafter there was no further improvement. RhGH was stopped because of transplantation in 29 patients at a mean+/-SD age of 12.1+/-4.0 years. Mean Ht SDS was -1.8+/-0.8 at transplant and there was no change over the following 5 years. In conclusion, treatment with rhGH resulted in improvement in Ht SDS in conservatively managed CRF for up to 3.0 years and for 1 year in children on dialysis. Discontinuation of rhGH after transplantation resulted in little change in Ht SDS  ISSN : 0931-041X  Journal Name : Pediatric Nephrology  Volume : 20  Issue Number : 5  Publishing Year : 1426 AH 2005 AD  Article Type : Article  Added Date : Sunday, March 16, 2008  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email جميلة قاري Kari, Jameela Investigator Doctorate   Files File Name Type Description  X30M381404466271(growth hormone).pdf pdf مشاهدة المقالة العلمية كاملة Back To Researches Page