Document Details

Document Type : Article In Journal 
Document Title :
Chlorambucil therapy in children with steroid-resistant nephrotic syndrome
Chlorambucil therapy in children with steroid-resistant nephrotic syndrome
 
Document Language : English 
Abstract : Chlorambucil (CHL) had been used as treatment for childhood nephrotic syndrome (NS) for more than half a century.1 It was used mainly in children with steroid sensitive nephrotic syndrome (SSNS) as steroid sparing agent in those with frequent relapsing or steroid dependent course.2 However, it was observed to result in higher rates of severe side effects and recommended as a second line drug after cyclophosphamide (CYC), which is considered as safer alkylating agent.2 The alkylating agents have been used for treating steroid resistant nephrotic syndrome (SRNS).2 However, CYC was used in most of the studies,3 while CHL was used only rarely.4,5 Elzouki et al showed in a small study that CHL induced complete or partial remission in patients with SRNS caused by either focal segmental glomerulosclerosis (FSGS) or mesangial proliferative glomerulonephritis (MPGN).4 In this retrospective study, we report our results of using CHL in children with SRNS secondary to IgM nephropathy, FSGS or diffuse mesangial hypercellularity (DMH). 
ISSN : 1658-3175 
Journal Name : Saudi Medical Journal 
Volume : 27 
Issue Number : 4 
Publishing Year : 1427 AH
2006 AD 
Article Type : Article 
Added Date : Sunday, March 16, 2008 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
جميلة قاريKari, Jameela InvestigatorDoctorate 
حماد الشايعAlshaya, Hammad ResearcherDoctorate 

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