Document Details Document Type : Article In Journal  Document Title : PROTEASOME INHIBITOR NOVEL TREATMEN IN MULTIPLE MYELOMA PROTEASOME INHIBITOR NOVEL TREATMEN IN MULTIPLE MYELOMA   Subject : Hematology  Document Language : English  Abstract : Multiple myeloma remains an incurable B-cell malignancy, necessitating urgent development of novel treatment. The proteasome is a ubiquitous and essential intracellular enzyme that degrades many proteins regulating cell cycle, apoptosis, transcription, cell adhesion, angiogenesis, and antigen presentation. PS-341 is a proteasome inhibitor that halts the cell cycle, resulting in apoptosis. It also inhibits a key transcription factor and has antiangiogenic activity and represents a novel potential anti cancer therapy. PS-341 has recently enrolled in many clinical trails for the treatment of multiple myeloma.  ISSN : 1110-211X  Journal Name : Mansoura Medical Journal  Volume : 36  Issue Number : 1  Publishing Year : 1426 AH 2005 AD  Article Type : Review Article  Added Date : Monday, May 12, 2008  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email فاتن السايس Al-Sayes, Fatin Investigator Doctorate   محمود الاحول Al-Ahwal, Mahmoud Researcher Doctorate   Files File Name Type Description  Proteosome_Inhibitors_(27).pdf pdf مشاهدة المقالة العلمية كاملة Back To Researches Page