Personal Information

 Professor

Department of الكائنات المعدية الخاصة

King Fahd Medical Research Center

Contact Information

Phone: 0126958000 Ext. 25185

Email: sharakeh@gmail.com

Steve Mustapha Harakeh

 Professor

Profile

Professor Steve Harakeh received his B.Sc. and M.Sc. Degrees in biology from the
American University of Beirut, and then he received his Ph.D. in Microbiology
from the University of Surrey in the United Kingdom. He did his postdoctoral
fellowship at Stanford University, School of Medicine in the USA. Then became a
research associate in the same department.
Professor Steve joined the Linus Pauling Institute of Science and Medicine, where
he worked with Professor Pauling, one of the world's only two unshared Nobel
Laureate prizewinners and published scientific papers with him. Professor Harakeh
joined the American University in Beirut and worked there in the Faculty of
Science and Public Health. He then joined the King Fahd Medical Research
Center at King Abdulaziz University in the Kingdom of Saudi Arabia as a
Professor in the Special Infectious Agents Unit and held the position of Head of
Research in the Chair of the Prophetic Medicine at the Faculty of Medicine.
Professor Harakeh has received many scientific and research awards and grants
and has published nearly 250 scientific research papers in internationally peer-
reviewed and scientifically indexed journals (ISI). He was recently ranked among
the 2% best scientists worldwide by Stanford University system. He has written
several chapters in prestigious international scientific books. He has also
participated in, organized, and presented his research in several national and
international scientific conferences. He worked as a reviewer for a wide range of
international scientific journals.
Professor Harakeh’s research has focused on viruses such as AIDS, influenza,
coronaviruses, including (COVID-19), bacteria, antimicrobials, and their
associated resistance. He also worked on evaluating the biological efficacy of
nano-formulations of natural compounds, in the treatment of cancer, diabetes, and
wounds and their potential application to reduce the toxicity associated with the
use of conventional drugs. He is diligent in serving the community at large to help
find ways to reduce the severity of diseases and their impact on the public health
and the economy.

Education

  • 1976

    Bachelor degree from Biological SciencesFaculty of Science, American University of Beirut, , لبــــــنان

  • 1978

    Master degree from Biological SciencesFaculty of Science, American University of Beirut, , لبــــــنان

  • 1982

    Doctorate degree from MicrobiologyFaculty of Science, University of Surrey, , بريطانيا

  • 1985

    Doctorate degree from Department of Medical MicrobiologyMedicine, Stanford University, California, امــريــكـا

Employment

  • 1982-1986

    Research Associate, Stanford University, California, امــريــكـا

  • 1986-1988

    Vice President, International Medical Marketing, Washington, امــريــكـا

  • 1987-1987

    Adjunct Professor, Gonzaga University, Washington, امــريــكـا

  • 1988-1996

    Research Scientist (Virologist), Linus Pauling Institute, California, امــريــكـا

  • 1988-1996

    Visiting Scholar, Stanford University, California, امــريــكـا

  • 1996-1997

    Senior research scientist, Yamanuchi-Shaklee Corporation, Hayward, California, امــريــكـا

  • 1997-1997

    Senior Research Scientist, Scientific Services and Technologies Clorox Technical Center, Pleasanton, California, امــريــكـا

  • 1998-2005

    Assistant Professor, American University of Beirut, بيروت, لبــــــنان

  • 2005-2011

    Professor, Dr. Rath Research Institute, سانتا كلارا، كاليفورنيا, امــريــكـا

  • 2011-حاليا

    Professor , King Fahd Medical Research center, King Abdulaziz University , Saudi Arabia., Jeddah, المملكة العربية السعودية

Research Interests

  1. Steve Harakeh, Rajaa Al-Raddadi, Turki Al Amri, Soad Al-Jaouni, Hanaa Tashkandi, Mohammed Qari, Mohammed Moulaym, Alia Aldahlawi. Estimating the efficacy of Novel nanoformulations as potential agents for Breast Cancer Treatment. RDO, KAU, 2021.
  2. Rajaa Al-Raddadi, Steve Harakeh, Turki Al Amri, Soad Al-Jaouni, Mohammed Qari, Yousef Qari. Nano-formulations of Thymoquinone, Curcumin, Rutin, DIM, Pomegranate and Ellagic Acid for Treatment of Liver Cancer. RDO, KAU,2021.
  3. Mohammed Qari, Emad Aljahdali, Arwa Almasaudi, Turki Alamri, Soad Al-Jaouni, Soad Shaker, Isaac akefe, Shaker Mousa, Steve Harakeh, Effects of a novel nano formulation of pomegranate on Ehrlich carcinoma in mice and cisplatin associated hepatotoxicity. Deanship of Scientific Research (DSR), King Abdulaziz University (KAU), 2021.
  4. Turki Alamri, Ohood Adas, Soad Al-Jaouni, Mohammed Qari, Soad Shaker, Naglaa El-Shitany, Majed Mostafa, Shaker Mousa, Steve Harakeh,. Effect of Ellagic Acid on heart in the treatment of Diabetes in Sprague-Dawley Diabetic Rats. DSR, KAU, 2021.
  5. Rajaa Al-Raddadi, Yasar Mehmood, Turki Alamri, Anwar Hashem, Turki Abujamel, Esam Azhar, Mohammed Almuhayawi, Ahmad Khan, Gulab Fatima Rani, Steve Harakeh,. Kinetics of immune response to Covid-19 after the 3rd dose (booster) dose of mRNA. DSR, KAU, 2021.
  6. Soad Al-Jaouni, Iman Shafie, Turki Alamri, Mohammed Almuhayawi, Soad Shaker, Saber Hasan, Isaac Akefe, Shaker Mousa, Steve Harakeh,.Modulation of cisplatin Oxidative nephro-toxicity by a novel Nano-formulation of rutin in Ehrlich Carcenoma Mice Model. DSR, KAU, 2021.
  7. Arwa Almasaudi, Saad Almuhayawi, Turki Alamri, Mohammed Qari, Soad Shaker, Addisu Tekemariam, Isaac Akefe, Saber Hassan, Shaker Mousa, Steve Harakeh,. Effects of a novel nano formulation of Ellagic acid against cisplatin inducedhepatotoxicity in mice with Ehrlich carcinoma. DSR, KAU, 2021.
  8. Mohammed Moulay, Soad Al-Jaouni, Amr Yakout, Waleed El-Said, Mohammed Almuhayawi, Anwar Hashem, Turki Abujamel, Turki Alamri, Mohammed Qari, Shaker Mousa, Steve Harakeh, Hydrothermal Assisted Fabrication of NS dopted Carbon Nanodots and their Utalization for Drug Delivery and Cell Imaging. DSR, KAU, 2021.
  9. Majed Almshjary, Gulab Fatima Rani, Turki Alamri, Thamed Andijani, Mohammed Qari, Rajaa Al-Raddadi, Yaser Mahmood, Steve Harakeh. Genetic Mechanisms of Hemoglobin F induction Therapy in Transfusion Dependent Thalassemia. DSR, KAU, 2021.
  10. Azhar Najjar, Khaled Abdrabo, Turki Alamri, Turki Abujamel, Shadi Zakaie, Mohammed Almuhayawi, Saber Hassan, Elhajjaj Hasan, Steve Harakeh,. Polyhydroxyalkanoates production from sugarcane molasses and subsequent utilization of de-bioplastic bacterial biomasses in biosorption of industrial dye, congo red from freshwater ecosystems. DSR, KAU, 2021.

  11. Manal Naseeb, Eram Albajri, Arwa Almasaudi, Muna Alamoudi, Turki Alamri, Soad Aljaouni, Ahmad Shaker, Haleema Alnahari, Steve Harakeh, Hormonal profile and immune-expression of proliferating cell nuclear antigen (PCNA), casapase-3 and thyroglobulin in thyroid gland of diabetic rats: Possible amelioration with the red grape seed extract (Proanthocyanidin). DSR, KAU, 2021.

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  12. Hanaa Tashkandi, Saad Almuhayawi, Turki Alamri, Soad Al-jaouni, Saber Hassan, Soad Shaker, Isaac Akefe, Shaker Mousa, Steve Harakeh, Effects of a novel nano formulation of Ellagic acid against cisplatin induced spleen toxicity in mice with Ehrlich carcinoma. DSR, KAU, 2021.
  13. Yousef Almehmadi, Abeer Almohammadi, Soad Shaker, Soad Al-jaouni, Rajaa Al-Raddadi, Turki Alamri, Saber Hassan, Isaac Akefe, Shaker Mousa, Steve Harakeh,. Modulation of cisplatin Oxidative testicular toxicity by a novel Nano-formulation of Ellagic acid in Ehrlich Carcenoma Mice Model. DSR, KAU, 2021.
  14. Badra Al Ghamdi, Emad Hassanian, Steve Harakeh. Study of the possible protective effects of vinpocentine against methotrexate-induced neuronal damagein rats. DSR, KAU, 2021
  15. Rajaa Al-Raddadi, Steve Harakeh, Turki Al Amri, Marwan Bakerman, Mohammed Al-Rabiea, Sami Alzahrani. Estimating burden of Covid 19 on Saudi Arabia Health System during the Pandemic. DSR, KAU, 2020.
  16. Turki Alamri, Ohod Adas, Steve Harakeh, Soad Al-Jaouni, Soad Shaker, Naglaa El-Shitany, Saber Hassan, Elhajjaj Hasan, Shaker Mousa. Effect of Ellagic Acid on liver in the treatment of Diabetes in Sprague-Dawley Diabetic Rats. DSR, KAU, 2020.
  17. Azhar Najjar, Saber Hassan, Steve Harakeh, Turki Abu Jamel, Esam Azhar, Addisu Tekemariam, Turki Alamri, Leena Azhar, Elhajjaj Hasan. Concomitant approach of liquid and gas biofuel production from starchy wastewater by oleaginous yeast biomass and the anaerobic bacteria Clostridium. DSR, KAU, 2020.
  18. Mohammed Almuhayawi, Nidal Zabermawi, Steve Harakeh, Turki Alamri, Addisu Teklemariam, Turki Abu jamel, Saad Almasaudi, Esam Azhar, Saber Hassan, Elhajjaj Hasan. Industrial optimization of biodiesel production from cooking oil wastes by nanocomposite encapsulated Kocuria flava lipases. DSR, KAU, 2020.
  19. Mohammed Qari, Zakariya Abd Elmajeed, Steve Harakeh, Turki Alamri, Soad Shaker, Naglaa El-Shitany, Rajaa Al-Raddadi, Shaker Mousa. Effects of a novel nano formulation of Pomegranate against cisplatin induced spleen toxicity in mice with Ehrlich carcinoma. DSR, KAU, 2020.
  20. Saad Almasaudi, Marwan Bakerman, Turki Alamri, Steve Harakeh, Rowaida Bawaked, Kalamegam Gauthman, Mohammed Almuhaywai, Peter Pushparaj, Esam Azhar, Ahmed Mirza. Influence of microbiota and food habits on the inflammatory cytokines:Additional insight to obesity. DSR, KAU, 2020.
  21. Sultan Alamri, Hanaa Tashkandi, Huda Abu Araki, Esam Azhar, Soad Al-Jaouni, Mohammed Almuhayawi, Steve Harakeh, Naglaa El-Shitany, Soad Shaker, Turki Alamri, Shaker Mousa. A Novel Nano- Ellagic acid Formulation for Treatment of Wounds in Diabetic Rats. DSR, KAU, 2020.
  22. Turki Al Amri, Areej AlKhaldy, Steve Harakeh, Esam Azhar, Mohammed Moulay, Kalamegam Gauthaman, Peter Pushparaj, Abdulrahman B. Mohamed, Salah Barnawi, Yousef Qari, Ahmad Mirza. Growth Factors in Relation to Obesity, Food Habits and Microbiota among Healthy Saudis. Deanship of Scientific Research (DSR), King Abdulaziz University (KAU), 2019.
  23. Saad Al Muhayawi, Manal Shafi, Soad Shaker, Steve Harakeh, Nagla El-Shitani, Mohammed Almuhayawi, Turki Al Amri, Shaker Mousa. Modulation of cisplatin Oxidative testicular toxicity by a novel Nano-formulation of rutin in Ehrlich Carcenoma Mice Model. DSR, KAU, 2019.
  24. Yousef Qari, Hanaa Tashkandi, Steve Harakeh, Turki Al Amri, Mohammed Almuhayawi, Emad Aljahdali, Shaker Mousa. Modulation of Cisplatin Nephrotoxicity by a Novel nano-formulation of Thymoquinone in Ehrlich Carcinoma Mice Model. DSR, KAU, 2019.
  25. Sultan Alamri, Abear Moharram, Mohammed Almuhayawi, Steve Harakeh, Turki Al Amri, Soad Shaker, Naglaa El-shitani, Ahmad Mirza, Shaker Mousa. A Novel Nano- rutin Formulation for Treatment of Wounds in Diabetic Rats. DSR, KAU, 2019.
  26. Steve Harakeh, Zeina Sharawi, Soad Shaker, Turki Al Amri, Kawthar Zaher, Naglaa El-Shitani, Shaker Mousa. A Novel Nano-formulation of Ellagic Acid protection against nephrotoxicity in diabetic Rats. DSR, KAU, 2019.
  27. Mohammed Qari, Nisreen Rajih, Steve Harakeh, Turki Al Amri, Soad Shaker, Nagla El-Shitani, Shaker Mousa. Novel Nano-formulation of Ellagic Acid protection against testicular damage in diabetic Rats. DSR, KAU, 2019.
  28. Saad Al-Masaudi, Emad Aljahdali, Turki Al Amri, Steve Harakeh, Mohammed Almuhayawi, Soad Shaker, Nagla El-Shitani, Aleksandara Niedwiecki, Mathias Rath. Protective and therapeutic potential of a novel phytobiologic formulation consisting of (curcumin, resveratrol, green tea extract, quercetin, and cruciferex) against ulcer. DSR, KAU, 2019.
  29. Soad Shaker, Ahmad Ali, Turki Al Amri, Steve Harakeh. Immunoexpression of proliferating cell nuclear antigen (PCNA), caspase 3, and thyroglobin in thyroid gland of diabetic rat: Ameriloration with proanthocyanidin. DSR, KAU, 2019.
  30. Ishtiq Qadri, Addisu, Turki Al Amri, Steve Harakeh. Isolation, characterization and biocontrol roles of wastewater bacteriophages against MDR bacteria from Jeddah, Saudi Arabia. DSR, KAU, 2019.

  31. Azhar Najjar, Nidal Zabermawi, Steve Harakeh, Saad Al-Masaudi, Mohammed Moulay, Elhagag Hassan, Ishtiq Qadri. Improvement the Catalytic Activity of Hyperthermophilic Bacterial Lipases for Enzymatic Biodiesel Production from Waste Cooking Oils over a Broad Range of Temperatures. DSR, KAU, 2019.

    32.  

  32. Mohammed Moulay, Saleh Alkarim, Steve Harakeh, Raed Azhar. Establishing a new stable prostate cancer cell lines derived from Saudi Patients. DSR, KAU, 2019.
  33. Mohamad H. Qari, Wafaa S. Ramadan, Soad K. Al Jaouni, Mohammed S. Al Muhayawi,Turki Al Amri, Ghulam Md Ashraf , Dhruba J Bharali, Shaker A Mousa, Steve Harakeh. Novel Nano-formulation of Ellagic Acid in Restoring Oxidative Homeostasis in Rat Brains with Alzheimer. DSR, KAU, 2018.
  34. Soad Al Jaouni, Wafaa Ramadan, Steve Harakeh, Torki Alzogaibi, Mohammed Al Muhayawi, Ahmad Mirza, Shaker Mousa, Dhruba Bharali. Effects of a Novel Nano-formulation of Pomegranate on the Chemoresistance and Nephrotoxicity of Cisplatin-treated Animals. DSR, KAU, 2018.
  35. Soad Al Jaouni, Steve Harakeh, Soad Shaker, Saad Al-Masaudi. Evaluation of The Anti-Diabetic Efficacy of a Novel Nano-formulation of Ellagic Acid in Rats. DSR, KAU, 2017.
  36. Ahmad Mirza, Soad Al Jaouni, Wafaa Ramadan, Rajaa Al-Raddadi, Turki Alamri, Steve Harakeh, Shaker Mousa. Effects of a Novel Nano-formulation of Curcumin on the Chemoresistance and Nephrotoxicity of Cisplatin-treated Animals. DSR, KAU, 2018.
  37. Steve Harakeh, Saad Al-Masaudi, Soad AL Jaouni, Turki Al Amri, Shaker Mousa, Dhruba Bharali. A novel Nano-curcumin Formulation for Treatment of Wounds in Diabetic Rats. DSR, KAU, 2018.
  38. Saad Al-Masaudi, Steve Harakeh, Turki Al Amri, Torki Alzugaibi, Rajaa Al-Raddadi, Mohammed Almuhayawi, Soad Shaker, Etidal Hewitt. Protective and therapeutic Potential of a Novel Formulation against Ulcer. DSR, KAU, 2018.
  39. Mohammed Almuhayawi, Soad Shaker, Steve Harakeh, Areej Alkhaldy, Turki Al Amri, Soad Al Jaouni. A Novel Nano-pomegranate Formulation for Treatment of Wounds in Diabetic Rats. DSR, KAU, 2018.
  40. Mohammed S. Al Muhayawi,Wafaa S. Ramadan, Steve Harakeh, Soad K. Al Jaouni, Dhruba J Bharali, Shaker A Mousa and Saad M Al Muhayawi. Neuroprotective and Therapeutic Effect of Pomegranate Extract and its Nanoparticles in ALCL3 induced Alzheimer Rat Model. DSR, KAU, 2018.
  41. Saad Al-Masaudi, Steve Harkeh, Mohammed Barakat, Soad Al Jaouni. In vitro antibacterial activity of honey against diarrhea causing bacterial isolates. DSR, KAU,2017.
  42. Abdulaziz N Alagaili, Steve Harakeh, Esam Azhar, Matthew Cotton, Alimuddin Zumla. What About Horses? Prevalence of Betacoronaviruses Including Mers-Cov Among Horses In Saudi Arabia. Accepted Kacst. 2017.
  43. Steve Harakeh, Anwar Hashem, Ayman Talat Abbas and Esam Azhar. Novel Biomarkers Associated with the Spike Gene of the Middle East Respiratory Syndrome Coronavirus isolated from Animals and Humans in Saudi Arabia. Accepted by Kacst. 2017.
  44. Ghada MA. Ajabnoor, Aliaa Alamoudi, Gehan Abdel Fattah Hegazy, Aleksandra Niedzwiecki, Steve Harakeh. Evaluation of a novel anticancer formulation for the treatment of breast cancer. DSR, KAU. 2016.
  45. Maryam AL-Gamdi Etimad Huwait, Ashwag Albukhari, Aleksandra Niedzwiecki, Steve Harakeh.Evaluation of a Phytochemical Combination for Colorectal Cancer Supportive Treatment. DSR, KAU. 2016.
  46. Saad Masaudi, Ayman Talat Abbas, Nagla A. El-Shitany and Steve Harakeh. Protective and therapeutic potential of a novel formulation against ulcer in the presence and absence of local Saudi honey. DSR, KAU. 2016.
  47. Saad Masaudi Muhammad Barakat Hussain and Steve Harakeh. Evaluation of antibacterial activity of honey and generation of honey resistant phenotypes among enteric pathogens. DSR, KAU. 2016.
  48. Steve Harakeh, Anwar Hashem, Ayman Talat Abbas.Novel Biomarkers Associated with the Spike Gene of the Middle East Respiratory Syndrome Coronavirus isolated from Animals and Humans in Saudi Arabia.Kacst Strategic. 1,500,000. 2015.
  49. Saad Masoudi, Steve Harakeh, Ayman Talat Abbas, Soad Shaker Ali Evaluation of antimicrobial and anti-ulcerative effects of Saudi honey. 160,000. King Abdulaziz University (KAU) Deanship for Scientific research (DSR) (2014).
  50. Taha Kumosani, Elie Barbour andSteve Harakeh.Development of safe and specific vaccines against prevalent drug-resistant avian influenza viruses in the domestic poultry of the Kingdom of Saudi Arabi. Kacst Strategic. 1,923, 689 SAR. (2015).
  51. Steve Harakeh, Ahmed Al-Hejin. Effect of Ascorbic Acid on Tax-dependent Activation of Nuclear Factor Kappa B and Matrix Metalloproteinase 9 in HTLV-1 Infected and Non-Infected Malignant T-Lymphocytes. KAU DSR (2014).
  52. TahaKumosani, Elie K. Barbour, Steve Harakeh andArchana P Iyer Identification of Salmonella serovars in Saudi Arabia in compliance with assurance threshold by GFN-EQAS of the World Health Organization. 270,900. KAU DSR (2013).
  53. Hani Hassan andSteve Harakeh Tax-dependent activation of Nuclear Factor Kappa B and of Matrix Metalloproteinase 9 in Human T-cell Lymph Trophic Virus 1- Positive Leukemia Cells by Green Tea Extract. 50,000 KAU DSR (2013).
  54. Steve Harakeh, Suhad Bahigri, Ahmed Hejin Microbiota Biomarkersin Obese patients in Saudi Arabi. 883,000 SAR. Kacst Large Grants (2014).
  55. Steve Harakeh (P.I.) Esam Azhar, Saad Masaudi Novel Strategy for Alleviation of Bacterial Drug-Resistance by a Nutrient Synergy. 156,000. KAU DSR (2013).
  56. Diaa Yousef (P.I). Lamia Shala, Jihan Ibrahim andSteve Harakeh Bioactive secondary metabolites and biosynthetic genes from Red sea Actinomycete. 1,648,150. Kacst Strategic. (2014).
  57. Taha Kumosani, Esam Azhar, Steve Harakeh, Archana Iyer and Elie Barbour. Established avian model for pathogenesis of Eimeria spp. allowing for evaluation of new holistic preventive control of coccidiosis. 50,000. KAU, DSR. d/32/67459.

Scientific interests

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Areas of expertise