Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Effects of Chemical Migrants from Two Widely Used Plastics on Reproduction in Mice تأثير المرتشحات الكيميائية من نوعين من البلاستيك شائعي الاستخدام على الحمل في فئران التجارب |
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Document Language |
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English |
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Abstract |
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Journal of Health Science, 52(4) 397-405 (2006) 397
Effects of Chemical Migrants from Two Widely Used Plastics on Reproduction in Mice
Al-Ser Abdulgader Al-Khatim*,a and Khalid El-Tom Alib
aDepartment of Environmental Health, Faculty of Environmental Sciences, King A. Aziz University, Jeddah-21589, P.O. Box 80208, Saudi Arabia and bDepartment of Biochemistry and Nutrition, Faculty of Medicine, University of Gezira, Wad Medani, P.O. Box 281, Sudan (Received February 19, 2006; Accepted May 8, 2006)
Two plastic items were investigated for toxicity, due to chemical migrants, on reproduction and subsequent pregnancy outcomes. Extraction of high-density polyethylene (HDPE) food oil jerrycans, and polyvinyl chloride (PVC) blood bags was carried out. HDPE and PVC were extracted with sesame oil and normal saline, respectively. The extracts were prepared daily and administered (50 ml/kg b.w.) into pregnant Swiss albino mice from gestation day 0 until delivery. Control groups received the pure vehicles that were subjected to the same conditions of extrac-tion and extracts. Pregnancy weight gain, gestation period, litter size, stillbirths and offspring sex ratio were re-corded. Blood sex hormones (progesterone, estradiol and prolactin) were assayed for each pregnancy trimester. Birth weight, growth rate and sex hormone levels [females: follicle stimulating hormone (FSH), leutenizing hor-mone (LH) and estradiol (E2); males: testosterone] were monitored in offspring (until the age of 30 days). ELISA was applied to assay hormones. HDPE caused significant (p 0.01) stillbirth. Blood hormone levels in dams and offspring for both treat-ments indicated no significance. PVC treatment exhibited negative effects on all parameters. In conclusion, HDPE is leachable and could affect reproduction, as indicated by the stillbirth incidence. PVC sample might not be toxic at the conditions of the experiment. Oil-plastic extract could exhibit a pronounced effect on pregnancy outcomes in contrast with the aqueous one. |
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ISSN |
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1347-5207 |
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Journal Name |
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Journal of Health Science |
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Volume |
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52 |
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Issue Number |
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4 |
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Publishing Year |
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1426 AH
2006 AD |
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Article Type |
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Article |
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Added Date |
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Sunday, August 21, 2011 |
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Researchers
| السر عبدالقادر الخاتم | Al-Khatim, Al-Ser Abdulgader | Investigator | Doctorate | abuenas@hotmail.com |
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