Document Details

Document Type : Article In Journal 
Document Title :
Dysembryoplastic Neuroepithelial Tumor (DNT): Morphological and Immunohistochemical Features
Dysembryoplastic Neuroepithelial Tumor (DNT): Morphological and Immunohistochemical Features
 
Document Language : English 
Abstract : Dysembryoplastic neuroepithelial tumor is a rare mixed neuronalglial tumor. The recognition and correct diagnosis of dysembryoplastic neuroepithelial tumor is important because this tumor is curable by excision. The records of the Pathology Department at King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia, were reviewed for cases that were histologically diagnosed as dysembryoplastic neuroepithelial tumor between 2000 and 2007; five cases were found. The clinical, radiological, histological and immunohistochemical findings were reviewed. The ages ranged between 9 and 25 years. There were 2 males and 3 females. All patients were diagnosed with epilepsy. Three patients had temporal tumor and the other two had frontal tumors. Radiological evaluation showed non-enhancing mass without mass effect or vasogenic edema. All five cases were characteristically composed of small round oligodendroglia-like cells, astrocytes and mature neurones in varying proportions. Immunocytochemistry for glial fibrillary acidic protein and neuronal markers (neuron-specific enolase; and synaptophysin) highlights the astrocytic and neuronal components. The recognition of this tumor is very important because it is a surgically curable lesion with excellent prognosis. Pathologists need to be familiar with the characteristic histopathological findings to avoid unnecessary overtreatment by radiotherapy or chemotherapy. 
ISSN : 0969-711 
Journal Name : JKAU: Med. Sci., 
Volume : 14 
Issue Number : 3 
Publishing Year : 2007 AH
2007 AD 
Article Type : Article 
Added Date : Sunday, April 11, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
جودة المغربيAl-Maghrabi, Jaudah InvestigatorDoctorate 

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