تفاصيل الوثيقة نوع الوثيقة : مقال في مجلة دورية  عنوان الوثيقة : "Synapse elimination in botulinum toxin-paralysed rat muscles" "Synapse elimination in botulinum toxin-paralysed rat muscles"   لغة الوثيقة : الانجليزية  المستخلص : In order to determine the fate of the superfluous neuromuscular junctions (NMJs) formed during the course of botulinum toxin (BoTx)-induced paralysis, we have quantified the change in the total length of the nerve muscle contact area(s) following BoTx injection into rat calf muscles. The results indicate that: (1) at least some of the superfluous NMJs are eliminated following muscle recovery; (2) synapse elimination is a slow process, as 4 months after recovery it was not yet complete; (3) muscles with different content of type I and II fibers follow a different time course during synapse formation and elimination. We further investigated the possibility that the neural cell adhesion molecule (NCAM) would be the element whose loss from the NMJ might play a role in synapse elimination. Using immunofluorescence and immunoelectron microscopy we show that NCAM is exclusively localized between nerve terminals and Schwann cells and not between nerve terminals and muscle. This localization was maintained throughout paralysis and following recovery, suggesting that NCAM does not play a role in synapse elimination.  ردمد : 16135345  اسم الدورية : Journal of Neurology  المجلد : 241  العدد : 6  سنة النشر : 1994 هـ 1994 م  نوع المقالة : مقالة علمية  تاريخ الاضافة على الموقع : Sunday, March 28, 2010  الباحثون اسم الباحث (عربي) اسم الباحث (انجليزي) نوع الباحث المرتبة العلمية البريد الالكتروني شريف حسن Hassan, Sherif باحث دكتوراه   الملفات اسم الملف النوع الوصف  26217.1 1   الرجوع إلى صفحة الأبحاث