تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
"Calcitonin gene-related peptide-like immunoreactivity in botulinum toxin-paralysed rat muscles"
"Calcitonin gene-related peptide-like immunoreactivity in botulinum toxin-paralysed rat muscles"
 
لغة الوثيقة : الانجليزية 
المستخلص : Changes in calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) at the motor endplates of botulinum toxin-paralysed rat muscles were investigated using immunohistochemistry. One day following toxin injection, a dramatic increase in CGRP-LI was detected at the motor endplates and within preterminal axons of the soleus and gastrocnemius muscles. The upregulation of CGRP-LI persisted throughout the period during which muscle fibres were paralysed and new neuromuscular junctions were being formed by the growing sprouts. Decline of CGRP-LI at the motor endplates coincided with clinical recovery. Both up- and down-regulation of CGRP-LI took place earlier in the soleus than in the gastrocnemius muscle. Up-regulation of CGRP-LI was also detected in a subpopulation of motor axons in the sciatic nerves and in the spinal motor neurons innervating the paralysed muscles. These results indicate that levels of CGRP are regulated, at least partly, by changes in the target innervation. They also suggest an important role for CGRP in the regenerative processes following muscle paralysis. 
ردمد : 12374706 
اسم الدورية : Neuromuscular Disorders 
المجلد : 4 
العدد : 4 
سنة النشر : 1994 هـ
1994 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Sunday, March 28, 2010 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
شريف حسنHassan, Sherif باحثدكتوراه 

الملفات

اسم الملفالنوعالوصف
 26216.1 1 

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