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Faculty of Sciences
Document Details
Document Type
:
Article In Journal
Document Title
:
Increasing αvβ3 selectivity of the anti-angiogenic drug cilengitide by N-methylation
Increasing αvβ3 selectivity of the anti-angiogenic drug cilengitide by N-methylation
Subject
:
Chemistry
Document Language
:
English
Abstract
:
A subtle change: Structural changes upon amide bond methylation improve the selectivity of the anti-angiogenic drug Cilengitide, which after N-methylation at distinct positions discriminates between the closely related pro-angiogenic integrins αvβ3 and αvβ5 (see scheme).
ISSN
:
0570-0833
Journal Name
:
Angewandte Chemie - International Edition
Volume
:
50
Issue Number
:
40
Publishing Year
:
1432 AH
2011 AD
Article Type
:
Article
Added Date
:
Wednesday, April 25, 2012
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
Carlos Mas-Moruno
Mas-Moruno, Carlos
Researcher
Doctorate
Horst Kessler
Kessler, Horst
Researcher
Doctorate
Kessler@tum.de
Files
File Name
Type
Description
33022.pdf
pdf
Abstract
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