Document Details Document Type : Article In Journal  Document Title : PMF, cesium and rubidium nanoparticles induce apoptosis in A549 cells PMF, cesium and rubidium nanoparticles induce apoptosis in A549 cells   Subject : Biochemistry  Document Language : English  Abstract : Cancer becomes one of the leading cause of death in many countries over the world. Fourier-transform infrared (FTIR) spectra of human lung cancer cells (A549) treated with PMF (natural product extracted from PM 701) for different time intervals were examined. Second derivative and difference method were taken in comparison studies. Cesium (Cs) and Rubidium (Rb) nanoparticles in PMF were detected by Energy Dispersive X-ray attached to Scanning Electron Microscope SEM-EDX. Characteristic changes in protein secondary structure, lipid profile and changes in the intensities of DNA bands were identified in treated A549 cells spectra. A characteristic internucleosomal ladder of DNA fragmentation was also observed after 30 min of treatment. Moreover, the pH values were significantly increases upon treatment due to the presence of Cs and Rb nanoparticles in the PMF fraction. These results support the previous findings that PMF is selective anticancer agent and can produce apoptosis to A549 cells.  ISSN : 2070-3740  Journal Name : Proceedings of World Academy of Science, Engineering and Technology  Volume : 73  Issue Number : 2011  Publishing Year : 1432 AH 2011 AD  Article Type : Article  Added Date : Wednesday, February 15, 2012  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email فاتن عبدالرحمن خورشيد Khorshid, Faten A Researcher Doctorate fkhorshid@kau.edu.sa جيهان عبدالرؤوف A. Raouf, Gehan Researcher Doctorate gehan_raouf@hotmail.com سالم محمود الحميدي El-Hamidy, Salem M Researcher Master selhamidy@kau.edu.sa جيهان صالح العمري Al-Amri, Gehan Gehan Researcher Doctorate jehanalamri@hotmail.com نورة العتيبي Alotaibi, Nourah Researcher Doctorate phy_norah@hotmail.com طه عبدالله قمصاني Kumosani, Taha Abdullah Researcher Doctorate tkumosani@kau.edu.sa Files File Name Type Description  32292.pdf pdf Abstract Back To Researches Page