Document Details

Document Type : Article In Journal 
Document Title :
Preliminary Study in diagnosis and early prediction of Preeclampsia by Using FTIR Spectroscopy Technique
Preliminary Study in diagnosis and early prediction of Preeclampsia by Using FTIR Spectroscopy Technique
 
Subject : Biochemistry 
Document Language : English 
Abstract : Background: Preeclampsia is a heterogeneous condition, potentially involving several separate pathophysiological pathways; currently no clinical screening test is useful for prediction of preeclampsia development. Fourier-transform infrared spectroscopy (FT-IR) holds great promise for clinical chemistry measurements. Methods: FT-IR spectra of serum samples from pregnant women -14 patients and 31 normotensive were obtained. Absorbance ratios, second derivative spectra, ANOVA test and personal correlation statistical analysis were tacking in comparison studies. The parameters studied were proteins and lipids. Results: Different absorbance ratios for specific bands were calculated and plotted versus the patient samples. These ratios yielded statistically significant increase/decrease among the groups under investigation. The results showed that among the normotensive control group three subjects later developed preeclampsia. The results obtained from the IR-measured (amide A/amide B) ratio of serum confirmed, with 92.9 % confidence level, the effectiveness of this technique for the diagnosis of preeclampsia. Normotensive pregnant women who developed preeclampsia were considered as subjects at high risk. Conclusion: This study suggests, for the first time that FT-IR spectroscopy can be successfully used as an accurate and rapid test, for diagnosis and early prediction of preeclampsia, starting from 20 week of gestation. 
ISSN : 1097-8135 
Journal Name : Life Science Journal 
Volume : 8 
Issue Number : 2 
Publishing Year : 1432 AH
2011 AD 
Article Type : Article 
Added Date : Monday, December 26, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
جيهان عبدالرؤوفA. Raouf, Gehan ResearcherDoctorategehan_raouf@hotmail.com
عبدالرحمن لبيد المالكيAl-Malki, Abdulrahman LResearcherDoctoratealalmalki@kau.edu.sa
نسمه منصوريMansouri, Nesma ResearcherDoctoratenmansouri@kau.edu.sa
رقية محمد المحموديAl-Mahmoudi, Rogaia MResearcherMaster 

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