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Research remains my main area of interest particularly clinical research but I have valuable experience in laboratory research which involves collaborative work, in the following areas:
ENDOTHELIAL DYSFUNCTION, LIPIDS AND NITRIC OXIDE METABOLISM IN CHILDREN WITH CHRONIC RENAL FAILURE: This study is part of my MD thesis. We studied endothelial function which impaired early in atherogenesis in normotensive children with stable CRF and in controls matched for age and vessel diameter. We found that endothelium dependent dilatation is impaired in children with CRF. We studied also lipids and nitric oxide metabolism in those children.
INCIDENCE AND CAUSES OF LIPIDS AND LIPOPROTEIN ABNORMALITIES IN CHILDREN WITH RENAL DISEASE: This is a prospective study of lipid abnormalities in children with chronic renal failure conservatively managed or on peritoneal dialysis. Our results of 47 children wit CRF, confirmed previous reports that hypertriglyceridaemia correlates inversely with the progression of CRF and that total cholesterol in these children were at the upper limit of normal range. We found also that enteral feeding does not enhance hyperlipidaemia in children with CRF. This study was part of my MD thesis
CLINCOPATHOLOGICAL STUDY OF PRIMARY NEPHROTIC SYNDROME: In late 1990 I was involved in a research project studying the natural history of nephrotic syndrome in Saudi Arabia. Recently we had another study to monitor the trends of change in histopathology in childhood nephrotic syndrome in the western area of Saudi Arabia where we observed an increase incidence of FSGS.
FAMILIAL NEPHROTIC SYNDROME AND HLA ANTIGENS IN BENGALI CHILDREN: We have investigated the major histocompatibility complex class I and II loci in three Bengali families living in east London, with nine affected children with steroid-sensitive nephrotic syndrome. We have studied the affected children, the unaffected siblings and their parents.
FAMILIAL HYPOMAGNESEMIA WITH HYPERCALCIURIA AND NEPHROCALCINOSIS SYNDROME (FHHNC) IN SAUDI CHILDREN, which lead to collaborative a study with Swaziland to study CLDN16 genotype predicts the progression of renal failure in FHNCC.
CLINICAL RESEARCH: Since I have moved to KAUH and I had been running research in different aspects of clinical nephrology (look publications)
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