.Objective: To describe the pregnancy outcome in
women with systemic lupus erythematosus and other
connective tissue diseases attending a specialized high risk
clinic at the Royal London Hospital.
Methods: Retrospective review of 30 patients seen over
a 30-month period. Diagnoses included 18 patients with
lupus and 5 with mixed connective tissue disease. Patients
were evaluated following a standardized protocol.
Results: For all patients there were 28 (93%) live births
and 2 spontaneous abortions. Of the live births, 6 (21%)
were preterms and 5 (17%) were small for gestational age.
For the 18-lupus patients there were 17 (94%) live births
and one spontaneous abortion. Of the live births, 3 (18%)
were preterm, 25% were small for gestational age and one
From the Pediatrics Department, The Royal London School of Medicine and Dentistry, Queen Mary Westfield College, University of London, United
Received 15th January 2001. Accepted for publication in final form 17th March 2001.
Address correspondence and reprint request to: Dr. J. A. Khari, Assistant Professor and Consultant Pediatric Neurologist, Pediatrics Department, King
Abdulaziz University Hospital, PO Box 80215, Jeddah 21589, Kingdom of Saudi Arabia. Tel. +966 (2) 55677904. Fax. +966 (2) 26743781. E-mail:
had neonatal lupus erythematosus. Nine patients (30%)
were positive for anti Sjogren’s syndrome A antibodies: 7
systemic lupus erythematosus patients (39%) and 2 mixed
connective tissue disease patients. Eight patients were
positive for anti-phospholipid antibodies: 5 for anticardiolipin
and 3 patients for lupus anticoagulant.
Conclusion: Most pregnancies complicated by lupus do
well with no maternal or neonatal deaths in a
multidisciplinary high-risk clinic. However a high rate of
prematurity and small gestational age remains a problem