Document Details Document Type : Article In Journal  Document Title : EVALUATION OF THE HEPATOPROTECTIVE POTENTIAL OF JIGRINE تقييم إمكانات للكبد JIGRINEتقييم إمكانات للكبد JIGRINE   Subject : PHARMACY  Document Language : English  Abstract : Objective: To evaluate the hepatoprotective potential of jigrine pre-treatment on thioacetamide induced liver damage in rats. Methods: Albino rats (Wistar strain) were prophylactically treated with jigrine at two dose levels (0.5 ml and 1.0 ml/kg/day p.o.) for seven days. On days 6, rats were also given a single dose of thioacetamide (100 mg/ kg s.c.). Activity of jigrine against thioacetamide induced hepatotoxicity was also compared with silymarin (25 mg/kg/day p.o.). Biochemical parameters like serum AST, ALT, Na+, K+, tissue glutathione, tissue TBARS were estimated to assess the liver function. Biochemical observations were supplemented with histopathological examination of liver sections. Results: Thioacetamide administration increased the AST, ALT, Na+ and K+ levels in serum and TBARS in liver. Pre-treatment of the rats with jigrine or silymarin reduced the thioacetamide induced elevated levels of the above indices. Thioacetamide administration decreased the  ISSN : 416-421  Journal Name : Indian Journal of Pharmacology, 31: 416-421  Volume : 1  Issue Number : 1  Publishing Year : 1420 AH 1999 AD  Article Type : Article  Added Date : Wednesday, August 4, 2010  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email أفتاب أحمد عبدالسلام Abdulsalam, Aftab Ahmed Researcher Master   Files File Name Type Description  27569.bmp bmp    27572.jpg jpg   Back To Researches Page