تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Further evidence that activated protein C resistance can be misdiagnosed as inherited functional protein S deficiency.
Further evidence that activated protein C resistance can be misdiagnosed as inherited functional protein S deficiency.
 
لغة الوثيقة : الانجليزية 
المستخلص : A recent report that activated protein C (APC) resistance interferes with functional protein S (PS) assays prompted us to re-investigate two pedigrees previously diagnosed as having functional PS deficiency. APC resistance was demonstrated in all individuals with apparent functional PS deficiency. The latter diagnosis was shown to be due to the assay being non-linear, functional protein S becoming normal at higher dilutions. This observation, taken in conjunction with results of in vitru recovery studies with purified PS, leads us to conclude that APC resistance was the primary disorder in both pedigrees. The misdiagnosis of APC resistance as functional PS deficiency can be prevented by performing the PS assay at several dilutions, including concentrations lower than those recommended by PS assay manufacturers. Subjects previously diagnosed as having functional PS deficiency should be re-investigated for APC resistance. 
ردمد : 1365-2141 
اسم الدورية : British Journal of Haematology 
المجلد : 88 
العدد : 1 
سنة النشر : 1416 هـ
1994 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Sunday, April 25, 2010 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
F.E. PrestonPreston, F.E. باحث رئيسيدكتوراه 
عادل أبو زنادةAbuzenadah, Adel باحث مشاركدكتوراه 

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